Neuroprotective actions of androgens on motoneurons

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Neuroprotective actions of androgens on motoneurons.

Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens are critical for the formation of important neuromuscular sex differences, decreasing the magnitude of normally occurring cell death in select motoneuron pop...

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The biological activity of androgens is thought to occur predominantly through binding to intracellular androgen-receptors, a member of the nuclear receptor family, that interact with specific nucleotide sequences to alter gene expression. This genomic-androgen effect typically takes at least more than half an hour. In contrast, the rapid or non-genomic actions of androgens are manifested withi...

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ژورنال

عنوان ژورنال: Frontiers in Neuroendocrinology

سال: 2009

ISSN: 0091-3022

DOI: 10.1016/j.yfrne.2009.04.005